Tetrahedron

Cationic iridium-catalyzed enantioselective activation of secondary sp 3 C–H bond adjacent to nitrogen atom

S Pan, Y Matsuo, K Endo, T Shibata

文献索引：Pan, Shiguang; Matsuo, Yusuke; Endo, Kohei; Shibata, Takanori Tetrahedron, 2012 , vol. 68, # 44 p. 9009 - 9015

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被引用次数: 35

摘要

A cationic Ir (I)–tolBINAP complex catalyzed an enantioselective C–C bond formation, which was initiated by secondary sp3 C–H bond cleavage adjacent to nitrogen atom. A wide variety of 2-(alkylamino) pyridines and alkenes were selectively transformed into the corresponding chiral amines with moderate to almost perfect enantiomeric excesses. Alkynes were also investigated as coupling partners. The effect of alkyl structure in ...