Synthesis of 1??Aryl??1H??pyrazolecarbonitriles and related derivatives

JR Beck, MP Lynch, FL Wright

文献索引：Beck, James R.; Lynch, Michael P.; Wright, Fred L. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 555 - 558

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被引用次数: 6

摘要

Abstract The synthesis of 1-aryl-5-cyano-1H-pyrazole-4-carboxylic acid, ethyl esters 1 is described. Subsequent chemistry led to relatively simple and unique pyrazole derivatives. Most important of these are 1-aryl-5-(aminocarbonyl)-1H-pyrazole-4-carboxylic acids 2, which are chemical hybridizing agents in wheat and barley. The regioselective hydrolysis of 1-(3-chlorophenyl)-1H-pyrazole-4, 5-dicarboxylic acid, dimethyl ester (7b) and ...