Chemical Communications

Asymmetric synthesis of 2-arylpyrrolidines starting from γ-chloro N-(tert-butanesulfinyl) ketimines

E Leemans, S Mangelinckx, N De Kimpe

文献索引：Leemans, Erika; Mangelinckx, Sven; De Kimpe, Norbert Chemical Communications, 2010 , vol. 46, # 18 p. 3122 - 3124

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被引用次数: 21

摘要

Only a few γ-chloro N-(tert-butanesulfinyl)- and N-(p-toluenesulfinyl)imines have been synthesized and used in some specific nucleophile-induced cyclizations towards dimethyl (R)-1-(S)-tert-butanesulfinyl -2-phenylpyrrolidin-2-ylphosphonate 4g and (2R,1′S)-N-[(S)-p-tolylsulfinyl]-2-[(2-p-tolylsulfinylphenyl )triisopropylsilyloxymethyl]pyrrolidine. 11 Simultaneous with our work, the asymmetric synthesis of 2-substituted pyrrolidines in 81–90% yield (from the starting imine) and in 95 : 5–97 : 3 ...