Stereoselective synthesis of a novel pseudopeptide hapten for the generation of hydrolytic catalytic antibodies

AC Rodriguez, AP Ramos, GE Hawkes, F Berti…

文献索引：Rodriguez, Ana Chiva; Ramos, Anna Pico; Hawkes, Geoffrey E.; Berti, Federico; Resmini, Marina Tetrahedron Asymmetry, 2004 , vol. 15, # 12 p. 1847 - 1855

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被引用次数: 8

摘要

The synthesis of a novel hapten containing a 1, 4-diamino-2, 3-diolbutane core unit is described. The molecule contains four stereogenic centres and has been synthesised via a stereoselective route. The absolute stereochemistry of each stereogenic carbon atom has been assigned by nuclear Overhauser effect experiments carried out on a number of derivatives.