Novel tropane-based irreversible ligands for the dopamine transporter

…, JL Katz, S Wirtz, JB Justice, AH Newman

文献索引：Zou; Kopajtic; Katz; Wirtz; Justice Jr.; Newman Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4453 - 4461

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被引用次数: 35

摘要

3α-(Diphenylmethoxy) tropane (benztropine) and its analogues are tropane ring-containing dopamine uptake inhibitors that display binding and behavioral profiles that are distinct from cocaine. We previously prepared a benztropine-based photoaffinity label [125I]-(N-[4-(4'- azido-3'-iodophenyl) butyl]-3α-[bis (4'-fluorophenyl) methoxy] tropane,[125I] 1, that covalently attached to the 1-2 transmembrane spanning region of the dopamine ...