Octahydropyrrolo [3, 4-c] pyrrole: a diamine scaffold for construction of either α4β2 or α7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that …

…, JH Grønlien, H Ween, K Thorin-Hagene…

文献索引：Bunnelle, William H.; Tietje, Karin R.; Frost, Jennifer M.; Peters, Dan; Ji, Anguo; Li, Tao; Scanio, Marc J. C.; Shi, Lei; Anderson, David J.; Dyhring, Tino; Gronlien, Jens H.; Ween, Hilde; Thorin-Hagene, Kirsten; Meyer, Michael D. Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4126 - 4141

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被引用次数: 22

摘要

A series of 5-(pyridine-3-yl) octahydropyrrolo [3, 4-c] pyrroles have been prepared that exhibit high affinity to α4β2 and/or α7 nicotinic acetylcholine receptors (nAChRs). Simple substitution patterns have been identified that allow construction of ligands that are highly ...