Convergent kilogram-scale synthesis of dual orexin receptor antagonist

M Girardin, SG Ouellet, D Gauvreau…

文献索引：Organic Process Research and Development, , vol. 17, # 1 p. 61 - 68

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被引用次数: 24

摘要

... from the methyl benzoate 16 to biaryl acid 2 could therefore be carried out as a through process without isolation, thus decreasing the processing time on ... 2 with oxalyl chloride or thionyl chloride was difficult due to insolubility of the activated species in organic solvents. ...