Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads
MG Bursavich, D Dastrup, M Shenderovich…
文献索引：Bursavich, Matthew G.; Dastrup, David; Shenderovich, Mark; Yager, Kraig M.; Cimbora, Daniel M.; Williams, Brandi; Kumar, D. Vijay Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6829 - 6833
Abstract Mps1, also known as TTK, is a mitotic checkpoint protein kinase that has become a promising new target of cancer research. In an effort to improve the lead-likeness of our recent Mps1 purine lead compounds, a scaffold hopping exercise has been undertaken. Structure-based design, principles of conformational restriction, and subsequent scaffold hopping has led to novel pyrrolopyrimidine and quinazoline Mps1 inhibitors. These new ...
