Evaluation of some Mannich bases of conjugated styryl ketones and related compounds versus the WiDr colon cancer in vitro
JR Dimmock, OA Phillips, SL Wonko, RA Hickie…
文献索引：Dimmock, Jonathan R.; Phillips, Oludotun A.; Wonko, Sheri L.; Hickie, Robert A.; Tuer, Robert G.; et al European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 217 - 226
Abstract The series of Mannich bases and one group of related α-aminoketones which had either 1 or 2 sites for thiol alkylation were evaluated against the WiDr tumour in vitro. Maximum activity was found in the bis alkylating agents (12–64 times the activity of the reference compound, 5-fluorouracil) and one of these bis Mannich bases had confirmed activity against murine P388 lymphocytic leukemia. No correlations were found with either ...
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