Tetrahedron

Facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo (trimethylsilyl) methylmagnesium bromide

Y Hari, R Kondo, K Date, T Aoyama

文献索引：Hari, Yoshiyuki; Kondo, Ryosuke; Date, Koji; Aoyama, Toyohiko Tetrahedron, 2009 , vol. 65, # 42 p. 8708 - 8713

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被引用次数: 15

摘要

Benzofuran is a promising pharmacophore for drug discovery and a large number of synthetic methodologies for its derivatives have been developed. 1 However, the synthetic approaches to 2-unsubstituted benzofuran-3-carboxylates are limited, 2, 3, 4, 5, 5a, 5b and 5c while there are many methods for the synthesis of 2-substituted ones. 6, 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h and 6i The methods applicable to the synthesis of various 2-unsubstituted derivatives are only ...