The synthesis of arylpropionic acids and the quantitative relationship between the structure and the activation of fibrinolysis

…, V Rejholec, Z Roubal, O Němeček

文献索引：Kuchar, Miroslav; Brunova, Bohumila; Rejholec, Vaclav; Roubal, Zdenek; Nemecek, Oldrich Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 5 p. 1173 - 1187

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被引用次数: 9

摘要

Abstract A number of substituted 2-arylpropionic (IV) and 3-arylpropionic (V) acids were prepared and their activity in the activation of fibrinolysis and the inhibition of heat denaturation of serum albumin was evaluated. The results were worked up using the method of regression analysis. From the regression equations obtained it may be considered that both activities are affected mainly by the lipophilicity of the aromatic ...