Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged L-leucyl-L-leucine methyl esters that control apoptosis of immune cells

H Mizuta, S Watanabe, Y Sakurai, K Nishiyama…

文献索引：Mizuta, Hironori; Watanabe, Soichiro; Sakurai, Yuji; Nishiyama, Keiko; Furuta, Toshiaki; Kobayashi, Yoshiro; Iwamura, Michiko Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 675 - 683

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被引用次数: 19

摘要

l-Leucyl-l-leucine methyl esters (LeuLeuOMe) is a lysosomotropic agent that induces apoptosis of certain immune cells. Glucose-carrying 2-nitrobenzyl (2-NB) and 2- nitrophenethyl (2-NPE) caged LeuLeuOMe, 1a and b, were synthesized and their photochemical and immunological properties were studied. Caged glycine methyl esters (GlyOMe), 2a, b, were also prepared to examine the cytotoxic activity of the photolytic ...