Organic letters

A Facile One-Carbon Homologation of Aryl Aldehydes to Amides

W Shen, A Kunzer

文献索引：Shen, Wang; Kunzer, Aaron Organic letters, 2002 , vol. 4, # 8 p. 1315 - 1317

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被引用次数: 29

摘要

The easily accessible 2-aryl-1, 1-dibromo-1-alkenes can be converted to amides under unusually mild conditions in good to excellent yields. Both electron-donating and electron- withdrawing substitutions on the aromatic rings are tolerated, and the reaction works well with hindered alkylamines. This simple homologation could find broad applications.