Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression

J Song, H Lee, YJ Kim, SY Kim, DS Kim…

文献索引：Song, Jiho; Kim, Young Jin; Min, Kyung Hoon; Lee, Hyun-E; Kim, Su Yeon; Kim, Dong-Seok Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6943 - 6946,4

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被引用次数: 4

摘要

5, 6, 7, 8-Tetrahydro-4H-cyclohepta [d] isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50= 0.67 μM), 8h (IC50= 1.01 μM) and 9b (IC50= 0.99 μM) exhibited a potent inhibitory activity approximately 85-to 126-fold greater than kojic acid, a well-known potent inhibitor. A ...