Discovery of imidazo [1, 2-a] pyrazine-based Aurora kinase inhibitors

DB Belanger, PJ Curran, A Hruza, J Voigt…

文献索引：Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174

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被引用次数: 32

摘要

The synthesis and structure–activity relationships (SAR) of novel, potent imidazo [1, 2-a] pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo [1, 2-a] pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.