Archiv der Pharmazie

Synthesis and Anticonvulsant Activity Evaluation of 7??Alkoxy [1, 2, 4] triazolo [3, 4??b] benzothiazol??3 (2H)??ones

DC Liu, XQ Deng, SB Wang, ZS Quan

文献索引：Liu, Da-Chuan; Deng, Xian-Qing; Wang, Shi-Ben; Quan, Zhe-Shan Archiv der Pharmazie, 2014 , vol. 347, # 4 p. 268 - 275

全文：HTML全文

被引用次数: 9

摘要

A new series of 7-alkoxy [1, 2, 4] triazolo [3, 4-b] benzothiazol-3 (2H)-ones were synthesized and evaluated for their anticonvulsant activities. Among these compounds, 7-propoxy [1, 2, 4] triazolo [3, 4-b] benzothiazol-3 (2H)-one (4c) and 7-butoxy [1, 2, 4] triazolo [3, 4-b] benzothiazol-3 (2H)-one (4d) showed the highest activity against maximal electroshock (MES)-induced tonic extension [effective dose (ED) 50: 11.4 and 13.6 mg/kg, respectively]. ...