Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine-aldoxime and-amidoxime hybrids as efficient uncharged reactivators of nerve agent- …

…, M Weik, L Jean, PY Renard, F Nachon, R Baati

文献索引：Renou, Julien; Loiodice, Melanie; Arboleas, Melanie; Baati, Rachid; Jean, Ludovic; Nachon, Florian; Renard, Pierre-Yves Chemical Communications, 2014 , vol. 50, # 30 p. 3947 - 3950

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被引用次数: 25

摘要

Abstract A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. These novel molecules display in vitro reactivation potencies towards VX-, tabun-and paraoxon-inhibited human AChE that are superior to those of the mono-and bis-pyridinium aldoximes currently used against nerve agent and ...