The role of a-glycerophosphoric acid, phosphorylcholine and phosphorylethanolamine in the biosynthesis of lecithins and cephalins has been recently established. 2 Three analogs have now been synthesized for use as potential inhibitors of the biosynthesis of the glycerophosphatides. Because of the chemical, and presumably also metabolic, stability of the carbon-phosphorus bond, it seemed of interest to prepare the phosphonate analogs of ...
