A derivative of the malonic semialdehyde was transformed by means of a bioconversion catalyzed by the enzyme l-threonine aldolase from E. coli into a 6: 4 epimeric mixture of two precursors of β-hydroxy glutamic acid. The enzyme was selective for the formation of the (S)- configuration at C-2, whereas the configuration at C-3 was not controlled. The two epimers were separated exploiting a diastereoselective acylation in organic solvent catalyzed by ...
