Synthesis and Characterization of Metabolites and Potential Impurities of the Antiulcerative Drug Tenatoprazole

…, M Khunt, K Mukkanti, P Pratap Reddy

文献索引：Reddy, Ganta Madhusudhan; Prasada Raju; Babu, J. Moses; Praveen; Khunt, Mayur; Mukkanti; Pratap Reddy, Padi Synthetic Communications, 2008 , vol. 38, # 11 p. 1725 - 1736

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摘要

Abstract Tenatoprazole (Ulsacare®) is a recently developed antiulcerative drug used for the treatment of both erosive and nonerosive gastroesophageal reflux disease. During the bulk synthesis of tenatoprazole, we have observed four impurities (tenatoprazole N??oxide, tenatoprazole sulfone N??oxide, N??methyl tenatoprazole, and desmethoxy tenatoprazole) and two metabolites (tenatoprazole sulfide and tenatoprazole sulfone). The present work ...