Tyramine fragment binding to BACE-1

…, D Schlatter, J Benz, A Ruf, D Roth, T Enderle…

文献索引：Kuglstatter, Andreas; Stahl, Martin; Peters, Jens-Uwe; Huber, Walter; Stihle, Martine; Schlatter, Daniel; Benz, Joerg; Ruf, Armin; Roth, Doris; Enderle, Thilo; Hennig, Michael Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1304 - 1307

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被引用次数: 55

摘要

Fragment screening revealed that tyramine binds to the active site of the Alzheimer's disease drug target BACE-1. Hit expansion by selection of compounds from the Roche compound library identified tyramine derivatives with improved binding affinities as monitored by surface plasmon resonance. X-ray structures show that the amine of the tyramine fragment hydrogen-bonds to the catalytic water molecule. Structure-guided ...