Organic letters

The decarboxylative strecker reaction

D Das, MT Richers, L Ma, D Seidel

文献索引：Das, Deepankar; Richers, Matthew T.; Ma, Longle; Seidel, Daniel Organic Letters, 2011 , vol. 13, # 24 p. 6584 - 6587

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被引用次数: 33

摘要

α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.