A novel prodrug strategy for extremely hydrophobic agents: Conjugation to symmetrically branched glycerol trimer improves pharmacological and pharmacokinetic …

…, T Matsushita, M Kamiya, H Hattori…

文献索引：Nemoto, Hisao; Kamiya, Masaki; Nakamoto, Aki; Katagiri, Ayato; Yoshitomi, Kohsuke; Kawamura, Tomoyuki; Hattori, Hatsuhiko Chemistry Letters, 2010 , vol. 39, # 8 p. 856 - 857

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被引用次数: 4

摘要

Management of a lipophilic–hydrophilic balance is a key element in drug design to achieve desirable pharmacokinetic characters. Therefore we have created unique modular molecules, symmetrically branched oligoglycerols (BGL), as an alternative way to endow