Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators

…, XZ Kong, CM Cheng, CY Li, XM Yang, Z Xing'E

文献索引：Yang, Ping; Kong, XiangZhen; Cheng, ChangMei; Li, ChangYan; Yang, XiaoMing; Zhao, Xing'E Science China Chemistry, 2011 , vol. 54, # 10 p. 1565 - 1575

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被引用次数: 3

摘要

Abstract Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are ...