Synthesis and biological activity of a novel class of purine nucleoside phosphorylase inhibitors
…, SP Walton, CH Williams, JA Montgomery
文献索引：Morris Jr., Philip E.; Elliott, Arthur J.; Walton, Sandra P.; Williams, Carl H.; Montgomery, John A. Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 379 - 404
Abstract Purine nucleoside phosphorylase.(PNP, EC. 2.4. 2.1) functions as a salvage enzyme in the purine and is important in the T-cell portion of the immune system As such, PNP is an important therapeutic target for diseases which are T-cell mediated. The biochemical basis for using PNP inhibitors as well as the various classes of inhibitors developed has been recently reviewed. Using X-ray crystallography we have designed ...
