Synthesis and preliminary biological characterization of a new potential 125 I-Radioligand for dopamine and serotonin receptors

…, N Cini, A Bottoncetti, S Raspanti, A Politi…

文献索引：Guarna; Menchi; Berti; Cini; Bottoncetti; Raspanti; Politi; Pupi Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3197 - 3206

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被引用次数: 16

摘要

The synthesis and a preliminary biological characterization of a new class of N-benzyl- aminoalcohols which have serotonin (5-HT2) and dopamine (D2) receptor affinity is described. In vitro competition binding studies were conducted with the new molecules and 3H-spiperone on crude membrane preparation from rat striatum and frontal cortex. One of these compounds, 3-benzylamino-1-(4-fluoro-2-iodophenyl)-propan-1-ol (6f), whose IC50 ...