A new class of analog of the bifunctional radiosensitizer. alpha.-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines

…, MA Stier, LM Werbel, CM Arundel-Suto…

文献索引：Suto; Stier; Werbel; Arundel-Suto; Leopold; Elliott; Sebolt-Leopold Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2484 - 2488

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被引用次数: 11

摘要

Radiotherapy continues to play a major role in the treatment of many forms of human cancer. 2 Although successful in some cases, ca. 30% of patients treated with radiation eventually succumb to lack of control of the primary disease. The failure of radiotherapy has been attributed to many factors, one of which is the presence of radioresistant hypoxic cells found in many solid tum0rs.~ 3'Studies have demonstrated that tumors contain various ...