Anti-tumoral activities of dioncoquinones B and C and related naphthoquinones gained from total synthesis or isolation from plants

…, G Zhang, A Hager, M Moos, A Irmer, R Bargou…

文献索引：Bringmann, Gerhard; Zhang, Guoliang; Hager, Anastasia; Moos, Michael; Irmer, Andreas; Bargou, Ralf; Chatterjee, Manik European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5778 - 5789

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被引用次数: 13

摘要

Dioncoquinones belong to a family of natural naphthoquinone products of interest due to their promising anti-tumoral and anti-infective activities. In particular, dioncoquinones A (5) and B (6) have been shown to be highly active against Leishmania major and multiple myeloma cells without any significant toxicity toward normal blood cells. Their effective concentrations against multiple myeloma cell lines were similar to those of melphalan, a ...