Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI??1)

…, V Limongelli, E Novellino, I Bauer, G Brosch…

文献索引：Castellano, Sabrina; Milite, Ciro; Ragno, Rino; Simeoni, Silvia; Mai, Antonello; Limongelli, Vittorio; Novellino, Ettore; Bauer, Ingo; Brosch, Gerald; Spannhoff, Astrid; Cheng, Donghang; Bedford, Mark T.; Sbardella, Gianluca ChemMedChem, 2010 , vol. 5, # 3 p. 398 - 414

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被引用次数: 42

摘要

Here we report the synthesis of a number of compounds structurally related to arginine methyltransferase inhibitor 1 (AMI-1). The structural alterations that we made included: 1) the substitution of the sulfonic groups with the bioisosteric carboxylic groups; 2) the replacement of the ureidic function with a bis-amidic moiety; 3) the introduction of a N-containing basic moiety; and 4) the positional isomerization of the aminohydroxynaphthoic moiety. We have assessed the biological ...