Antibody-catalyzed decarboxylative oxidation of vanillylmandelic acid

…, C Mioskowski, Y Frobert, P Pradelles…

文献索引：Taran; Renard; Bernard; Mioskowski; Frobert; Pradelles; Grassi Journal of the American Chemical Society, 1998 , vol. 120, # 14 p. 3332 - 3339

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被引用次数: 19

摘要

The most important industrial process for the synthesis of vanillin is performed in two steps involving an electrophilic aromatic substitution of glyoxylic acid on guaiacol followed by an oxidative decarboxylation of the intermediary α-hydroxy acids formed, thereby producing not only vanillin, but also byproducts which have to be eliminated. In the present study, we took advantage of the high specificity of catalytic antibodies to improve the synthesis of vanillin. ...