Tetrahedron Letters

A new efficient synthesis of 3-(4-pyridinyl) methylindoles

…, Y Li, KL Meagher, RG Mewshaw, BL Harrison

文献索引：Zhou, Ping; Li, Yanfang; Meagher, Kristin L; Mewshaw, Richard G; Harrison, Boyd L Tetrahedron Letters, 2001 , vol. 42, # 42 p. 7333 - 7335

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被引用次数: 14

摘要

A new efficient method for the preparation of 3-(4-pyridinyl) methylindoles has been developed. The new method involves coupling of indoles with 4-pyridinecarboxaldehyde to give 3-indolyl 4-pyridinyl methanols, which upon treatment with triethylsilane in the presence of trifluoroacetic acid afford 3-(4-pyridinyl) methylindoles in 64–76% overall yield.