Enzymatic preparation of an R-amino acid intermediate for a γ-secretase inhibitor

RL Hanson, RM Johnston, SL Goldberg…

文献索引：Hanson, Ronald L.; Johnston, Robert M.; Goldberg, Steven L.; Parker, William L.; Goswami, Animesh Organic Process Research and Development, 2013 , vol. 17, # 4 p. 693 - 700

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被引用次数: 9

摘要

(R)-5, 5, 5-Trifluoronorvaline, an intermediate for a γ-secretase inhibitor (BMS-708163) under development, was initially prepared from the corresponding keto acid using a commercially available d-amino acid dehydrogenase for reductive amination and glucose dehydrogenase for cofactor recycling. This amino acid could also be prepared using a d- amino acid transaminase with alanine as the amino donor, but the transamination also ...