Synthesis of peptide nucleic acid monomers containing the four natural nucleobases: thymine, cytosine, adenine, and guanine and their oligomerization

…, M Egholm, C Behrens, L Christensen…

文献索引：Dueholm, Kim L.; Egholm, Michael; Behrens, Carsten; Christensen, Leif; Hansen, Henrik F.; et al. Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5767 - 5773

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被引用次数: 344

摘要

The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described. The PNA monomers containing thymine, Cbz-protected cytosine, or adenine or benzyl-protected guanine were prepared via convergent syntheses. Subsequent to introduction of the carboxymethyl linker at N-1 of the pyrimidines or N-9 of the purines and suitable protection of exocyclic groups, the ...