A general synthesis protocol for the generation of tri-and tetrasubstituted 5- carbamoylhydantoins is described. Starting from barbituric acids and following bromination and reaction with primary amines, 5-aminobarbituric acids 3a-s and 8 were prepared. Compounds 3 and 8 were subjected to different conditions of a base-catalyzed rearrangement reaction to yield the 1, 5, 5-trisubstituted hydantoins 4a-s and the 1, 3, 5, 5- ...
![2,4,6(1H,3H,5H)-Pyrimidinetrione,1-ethyl-5-methyl-5-[(1-methylethyl)amino]-(9CI)结构式](https://image.chemsrc.com/caspic/133/569336-80-7.png)
