Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor

DJ Wallace, CA Baxter, KJM Brands…

文献索引：Organic Process Research and Development, , vol. 15, # 4 p. 831 - 840

被引用次数: 14

摘要

... Organic Process Research & Development. ... Process Res. ... step, however careful control of reagent charge was required as this protocol also led to some further debromination to starting material 9. On the basis of these issues it appeared the bromination procedure would likely ...

4282-46-6

3-(4-硝基苯基)-吡啶

Development of a Fit-for-Purpose Large-Scale Synthesis of an...

[Wallace, Debra J.; Baxter, Carl A.; Brands, Karel J. M.; Bremeyer, Nadine; Brewer, Sarah E.; Desmond, Richard; Emerson, Khateeta M.; Foley, Jennifer; Fernandez, Paul; Hu, Weifeng; Keen, Stephen P.; Mullens, Peter; Muzzio, Daniel; Sajonz, Peter; Tan, Lushi; Wilson, Robert D.; Zhou, George; Zhou, Guoyue Organic Process Research and Development, 2011 , vol. 15, # 4 p. 831 - 840]