Discovery of a novel series of benzoic acid derivatives as potent and selective human β3 adrenergic receptor agonists with good oral bioavailability. 3. …

M Imanishi, Y Nakajima, Y Tomishima…

文献索引：Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4804 - 4822

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被引用次数: 21

摘要

... Journal of Medicinal Chemistry. ... However, it was still insufficient in terms of β 3 -AR potency and long duration for OAB treatment, since in the field of treatment of urinary bladder dysfunction, there is an unmet medical need for a once daily oral administration. ...