Nitric oxide (NO) and its relatives (notably RSNO and HNO) perform important roles as regulatory molecules in health and disease.[1] NO activates guanylate cyclase by binding to its ferrous heme (see the Supporting Information, Figure S1). The lifetime of NO is short, being milliseconds to seconds,[1b] and therefore it is unlikely that NO diffuses more than approximately 100 μm, which is in the range of a few cells, from the site at which it is ...
