Synthesis, Pharmacophores, and Mechanism Study of Pyridin??2 (1H)??one Derivatives as Regulators of Translation Initiation Factor 3A

W Zhu, J Shen, Q Li, Q Pei, J Chen, Z Chen…

文献索引：Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun Archiv der Pharmazie, 2013 , vol. 346, # 9 p. 654 - 666

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被引用次数: 6

摘要

Twenty-seven 1, 5-disubstituted-pyridin-2 (1H)-one derivatives were synthesized and evaluated for their anti-cancer and anti-fibrosis activity by A549 and NIH3T3 cell viability assays, respectively. To study the selectivity between the cancer and fibrosis cell lines, pharmacophore models (F1–F4) were built in advance for compounds with pyridin-2 (1H)- one scaffold, which revealed the relationship between the occupation of the aromatic sub- ...