(Phosphinyloxy) acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogs of (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl …

DS Karanewsky, MC Badia, DW Cushman…

文献索引：Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469

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被引用次数: 24

摘要

7i phenylbuty1) phosphonous acid (6) l was coupled to the hydroxyacyl amino esters 7a-j to give phosphonous monoesters, which were subsequently oxidized to phosphonic monoesters Sa-j with sodium metaperiodate in aqueous dioxane.'V8 Removal of the N-Cbz and ester protecting groups gave the desired analogues 2a-j, isolated as their dilithium salts (Scheme I).