Tetrahedron letters

A short practical synthesis of 2′-deoxymugineic acid

…, G Crossley, S Ghosal, Y Lefievre, MW Pennington

文献索引：Singh, Satendra; Crossley, George; Ghosal, Saswati; Lefievre, Yann; Pennington, Michael W. Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1419 - 1421

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被引用次数: 27

摘要

A short and practical synthesis of 2′-deoxymugineic acid (DMA) has been developed via reductive alkylation with the aldehyde intermediates. No protection of azetidine-2-carboxylic acid was required and the presence of free carboxylic acid function facilitated purification by simple acid and base extractions. Furthermore, the intermediates were conveniently purified by HPLC due to the presence of chromophoric benzyl ester protecting group (s). ...