Folding and self-assembling with β-oligomers based on (1R, 2S)-2-aminocyclobutane-1-carboxylic acid

…, I Díez-Pérez, S Dannenberg, S Izquierdo…

文献索引：Torres, Elisabeth; Gorrea, Esther; Burusco, Kepa K.; Da Silva, Eric; Nolis, Pau; Rua, Federico; Boussert, Stephanie; Diez-Perez, Ismael; Dannenberg, Samantha; Izquierdo, Sandra; Giralt, Ernest; Jaime, Carlos; Branchadell, Vicen; Ortuno, Rosa M. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 3 p. 564 - 575

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被引用次数: 48

摘要

Improved methodologies are provided to synthesize (1R, 2S)-2-aminocyclobutane-1- carboxylic acid derivatives and their incorporation into β-peptides of 2–8 residues bearing different N-protecting groups. The conformational analysis of these oligomers has been carried out by using experimental techniques along with theoretical calculations. This study shows that these oligomers adopt preferentially a strand-type conformation in solution ...