Stable and selective hybridization of oligonucleotides with unnatural hydrophobic bases

M Berger, AK Ogawa, DL McMinn, Y Wu…

文献索引：Berger, Markus; Ogawa, Anthony K.; McMinn, Dustin L.; Wu, Yiqin; Schultz, Peter G.; Romesberg, Floyd E. Angewandte Chemie - International Edition, 2000 , vol. 39, # 16 p. 2940 - 2942

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被引用次数: 66

摘要

Abstract Relying on only interbase hydrophobic packing for bonding, several unnatural nucleobases similar to 1 can form selective and stable self-pairs in duplex DNA. These unnatural nucleobases should make it possible to increase the stringency and information content of hybridization or encoding experiments.