Tetrahedron Letters

An improved large scale procedure for the preparation of N-Cbz amino acids

AD Pehere, AD Abell

文献索引：Tetrahedron Letters, , vol. 52, # 13 p. 1493 - 1494

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被引用次数: 13

摘要

... Tetrahedron Letters. ... Tetrahedron, 32 (1997), pp ... Acetone (4.0 vol, with respect to the amino acid) was added and the slightly turbid solution was cooled in an ice water bath to 15–20 °C. Cbz-Cl (1.25 equiv) was added slowly, with stirring, and the reaction mixture allowed to warm ...