On isotope effects for the cytochrome P-450 oxidation of substituted N, N-dimethylanilines

JP Dinnocenzo, SB Karki, JP Jones

文献索引：Dinnocenzo; Karki; Jones Journal of the American Chemical Society, 1993 , vol. 115, # 16 p. 7111 - 7116

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被引用次数: 99

摘要

Abstract: Isotope effects were determined for the oxidative demethylation of the substituted N- methyl-N-(trideuteriomethy1) anilines la-d, and the corresponding N, N-bis (dideuteriomethy1) anilines 2a4, by microsomal cytochrome P-450. The pairs ofp-cyano- andp-nitro-N, N-dimethylanilines were found to have the same intramolecular isotope effects, while the unsubstituted and p-chloro derivatives had different isotope effects. It is ...