Stereospecific synthesis of enantiomers of 4-hydroxyglutamic acid and study of their inhibiting properties with respect to glutamine synthetase
VP Krasnov, LV Alekseeva, NA Firsova…
文献索引：Krasnov, V. P.; Alekseeva, L. V.; Firsova, N. A.; Kodess, I. K.; Burde, N. L. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 6 p. 369 - 372 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 6 p. 655 - 659
We have developed a new method for the stereospecific synthesis of enantiomers of acid I that is based on the use of glutamic acid derivatives that have genuine L or D configurations of the a-carbon atom. As the starting compound for the synthesis we used dimethyl esters of N-phthalyl-4-bromo-L-or D-glutamic acids (IVa, b), which were obtained by a method similar to that in [9] and were hydrolyzed with 20% HCI.
