Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent

…, SH Choi, JY Park, SH Choi, J Finn, SH Yoon

文献索引：Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039

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被引用次数: 62

摘要

A series of novel substituted pyridyl phenyl oxazolidinone analogues were synthesized and their structure–activity relationship (SAR) was investigated based on in vitro and in vivo antibacterial activities. The minimum inhibitory concentrations (MICs) of the synthesized compounds against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin- resistant enterococci (VRE) ranged from 0.12 to 2.0 μg/mL, and against Haemophilus ...