Chemistry Letters

Stereoselective Synthesis of (E)-and (Z)-. GAMMA.,. DELTA.-Unsaturated Ketones Using trans-2-Phenylthiocyclobutyl Ketones.

T Fujiwara, T Iwasaki, T Takeda

文献索引：Fujiwara, Tooru; Iwasaki, Toshiaki; Takeda, Takeshi Chemistry Letters, 1993 , # 8 p. 1321 - 1324

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被引用次数: 7

摘要

The reaction of 1-methoxymethyl-2-phenylthiocyclobutanes with phenylthiotrimethylsilane followed by hydrolysis gave (E)-and (Z)-γ, δ-unsaturated ketones with high stereoselectivity. The starting materials were easily prepared by the stereoselective addition of Grignard reagents to trans-2-phenylthiocyclobutyl ketones.