Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides

D Sriram, P Yogeeswari, RV Devakaram

文献索引：Sriram, Dharmarajan; Yogeeswari, Perumal; Devakaram, Ruth Vandana Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3113 - 3118

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被引用次数: 94

摘要

Various diclofenac acid hydrazones and amides were synthesized and evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. Preliminary results indicated that most of the compounds demonstrated better in vitro antimycobacterial activity (MIC: 0.0383–7.53 μM) than diclofenac (MIC: 21.10 μM) and ciprofloxacin (MIC: 9.41 μM). Among the synthesized compounds, 1-cyclopropyl-6-fluoro-8-methoxy-7-[[N4-(2-(2-( ...