Tetrahedron

An organo-catalytic approach to the enantioselective synthesis of (R)-selegiline

SK Talluri, A Sudalai

文献索引：Talluri, Siva Kumar; Sudalai, Arumugam Tetrahedron, 2007 , vol. 63, # 39 p. 9758 - 9763

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被引用次数: 31

摘要

N-Methyl-N-((R)-1-phenylpropan-2-yl)prop-2-yn-1-amine (1) (Selegiline), a levorotatory acetylenic derivative of phenethylamine is commonly referred to in the clinical and pharmacological literature as l-deprenyl. It is a selective, irreversible inhibitor of monoamineoxidase-B (MOA) and is quite effective in the treatment of Parkinson's disease as well as Alzheimer's disease 1, 1a and 1b when used along with l-DOPA. Selegiline (1) has been reported to retard the further ...