Synthesis and immunobiological activity of an original series of acyclic lipid a mimics based on a pseudodipeptide backbone

…, S Front-Deschamps, S Moutel, K Schindl…

文献索引：Martin, Olivier R.; Zhou, Wei; Wu, Xinfu; Front-Deschamps, Sophie; Moutel, Stephane; Schindl, Katharina; Jeandet, Patricia; Zbaeren, Claude; Bauer, Jacques A. Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 6000 - 6014

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被引用次数: 15

摘要

N δ-l-Homoserinyl-d-ornithinol pseudodipeptides N-acylated with typical Escherichia coli lipid A fatty acid residues and mono-O-or bis-O-phosphorylated have been prepared and their properties investigated. The derivatives carrying two phosphate groups were found to be inducers of NO production. In addition, while they were unable to induce significantly the production of interleukin-6 (IL-6) by human PBMC cells, these compounds behaved also ...